Figure 2: FRQ activities in circadian feedback loops are impaired in the frq codon-optimized strains. Figure 3: FRQ protein in the codon-optimized strains is less stable and more sensitive to trypsin ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...

Scientists have discovered a microbe that bends the rules of the genetic code. This organism, Methanosarcina acetivorans, uses a flexible translation process. One codon, UAG, traditionally a stop ...

There are 20 canonical amino acids that are encoded by the genetic code of nearly all known organisms - there are only very few exceptions. In order to add novel building blocks to this existing ...