Figure 2: FRQ activities in circadian feedback loops are impaired in the frq codon-optimized strains. Figure 3: FRQ protein in the codon-optimized strains is less stable and more sensitive to trypsin ...

For decades, biology has relied on one central assumption: the genetic code is precise. DNA is transcribed into RNA, RNA is ...

This unexpected flexibility in genetic decoding was observed in Methanosarcina acetivorans, a methane-producing organism from the Archaea domain. Instead of adhering to the conventional role of the ...

There are 20 canonical amino acids that are encoded by the genetic code of nearly all known organisms - there are only very few exceptions. In order to add novel building blocks to this existing ...